Fermentation Recovery & Purification Development

We utilize a number of advanced techniques to quickly establish processes that will yield the optimal outcome at the highest level of efficiency.

Upstream Process Development

For microbial processes, we have established separate laboratories with dedicated staff to match our capabilities in mammalian development.

Fermenter:

  • 10L wv Labfors Infors 5 (preferred scale for transfer)
  • 6 x 2L wv Sartorius Stedim Biostat B Twin (preferred scale for development and characteristics)

Homogenizer:

  • Panda Plus 2000

TFF system:

  • Akta Flux 6

Centrifuge:

  • Backman Coulter Avanti J-26

Downstream Process Development

We leverage a panel of state-of-the-art separation technologies and follow DoE principles to achieve maximum recovery and purity of target proteins. Required DSP process characterization is performed based on qualified scale-down models and is supported by high-throughput analytical instrumentation.

Our downstream process development capabilities for mammalian cell culture include:

  • Allegro™ Single-Use Tangential Flow Filtration
  • ÄKTA™ chromatography systems
  • Automated systems for filtration optimization

We can support any projects process development and utilize our know-how, state-of-the-art equipment and proprietary technologies to deliver a process optimized for your therapeutic.

HOW CAN WE HELP?

Whether you are looking to advance a biosimilar program, work on innovative molecules or learn more about our capabilities, we look forward to hearing from you.

Solutions

Analytical Development

All required physico-chemical and bioanalytical methods are established and qualified in-house to fully characterize relevant target protein quality attributes, including in-depth analysis of post-translational modifications.

Solutions

Microbial Fermentation Manufacturing

Learn about our state of the art cGMP capabilities for microbial fermentation.