Developing High Quality, High Titre Manufacturing Cell Lines with CHOBC®
Polpharma Biologics have over 25 years of success in generating high-yield production cell lines for innovative proteins.
Our proprietary CHOBC® expression platform allows rapid generation of high-quality cell lines with a completely animal component-free (ACF) process. High-throughput technologies are deployed to increase productivity and achieve the highest titers possible, while minimizing undesired species. We can also rapidly scale to 50 L production for early stage material or transfer to our manufacturing stream for process development and 50 – 2000 L cGMP production.
Our CHOBC® expression platform combines the following features:
- CHO-K1 derived suspension cell line
- Allows rapid generation of high-quality cell lines
- Completely animal component-free (ACF) process
- Grown in chemically defined media
- High-throughput technologies are deployed to increase productivity and achieve the highest titers possible, while minimizing undesired species
- Research cell banks are rigorously tested for the absence of viral elements in accordance with ICH guidelines.
- CHOBC® cell lines have already been successfully scaled-up to 1,000 L and used to produce drug substance for clinical trial supply.
- Competitive timelines from DNA to research cell bank
- Quick scale up to 50 L for pre-clinical supply
- Combine with our master cell banking, process development and manufacturing services for a fast route to IND
SLIM™ technology improves process efficiency and allows for further process optimization
Our Scientific Leverage of Innovative Metabolism (SLIM™) technology reduces feed consumption at much lower power input eliminating hardware limitations in upstream development, reducing the cost of development.
Enhance expression with SPOT™ technology to deliver up to 9 g/L
Our CHOBC® cell line delivers good tires as standard from 2-4 g/L but we have developed our SPOT™ (Specific Productivity Optimization Technology) which increases cell size and specific expression of the desired protein without increasing the amount of host cell protein or other undesired excipients. This significantly reduces downstream costs due to easier purification.
Accessing CHOBC®, SLIM™ and SPOT™ Technology
Polpharma Biologics offer their cell line development packages on a fee for service basis, this can either be as a stand alone cell line development project or as part of an integrated Idea to IND package. We can also work on improving your current cell lines productivity with our SLIM™ or SPOT™ technology.
Contact us today for more information or a quote.