Analytical Development

Utilizing our comprehensive (bio)-analytical toolbox

All required physico-chemical and bioanalytical methods are established and qualified in-house to fully characterize relevant target protein quality attributes, including in-depth analysis of post-translational modifications.

Platform Methods for Physical-Chemical Properties

  • Chromatographic methods (SEC, CEX, RP, HIC, HILIC)
  • Spectrophotometric methods (UV-VIS, FTIR, BCA, Fluorescence)
  • Electrophoretic methods (CE-SDS nonred, CE-SDS red)
  • Mass Spectrometry methods (LC-MS, CESI-MS)
  • High throughput chip electrophoresis for glycans, charge variants

Platform Methods for Biological Properties

  • Cell-based assays (luminescence-based, cytometry assays)
  • ELISA based methods
  • PCR

Our analytical services are designed to support our partners development projects to ensure the quality and purity of their therapeutics. However we will support any standalone analytical project so we can accelerate your product to patients.

Solutions

Discovery & Optimization

Our early stage antibody discovery and humanization platforms are designed to get you a high affinity antibody with the desired binding properties that is ready for the next stage of your project.

Solutions

Cell Line Development

Polpharma Biologics have over 25 years of success in generating high-yield production cell lines for innovative proteins.

Solutions

Process Development

Polpharma Biologics provides full process development support, from early development of mAbs to process and analytical methods development.

Solutions

Manufacturing

Our drug substance process development and manufacturing services are fully integrated across our site network for seamless process transfer, scale-up and end-to-end supply chain efficiency.